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May 1988

Etretinate for the Treatment of Lichen Amyloidosis

Author Affiliations

Gyöngyvér Soós Department of Dermatology Semmelweis Medical School 1085 Maria u 41 Budapest, Hungary

Arch Dermatol. 1988;124(5):657-659. doi:10.1001/archderm.1988.01670050015008

To the Editor.—  Lichen amyloidosis is a rare disease among whites. Treatment of the disease is often ineffective. Helander and Hopsu-Havu1 reported the beneficial effect of the synthetic aromatic retinoid, etretinate, on four patients with lichen amyloidosis. Herein we describe our experiences in two additional cases of lichen amyloidosis treated with etretinate (Tigason).

Report of Cases.—Case 1.—  A 57-year-old woman had had verrucous itching eruptions on her legs for eight years. Treatment with topically administered corticosteroids and psoralen plus ultraviolet A had no effect on her symptoms.Examination showed numerous, lichenified, firm papules and nodules of the lower legs (Fig 1).Results of laboratory tests revealed slightly elevated levels of glucose, with no glycosuria. Results of routine blood chemistry tests were normal. Urinalysis results were normal. Results of peripheral blood B-cell counts and T-cell subsets were within normal limits. Results of serum protein electrophoresis and immunoelectrophoresis were normal, and