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May 1988

Spreading Pigmented Actinic Keratosis: An Electron Microscopic Study

Author Affiliations

From the Departments of Dermatology (Drs Dinehart and Sanchez) and Pathology (Dr Sanchez), The University of Texas Medical Branch, Galveston. Dr Dinehart is now with the Division of Dermatology, Duke University Medical Center, Durham, NC.

Arch Dermatol. 1988;124(5):680-683. doi:10.1001/archderm.1988.01670050024012

• Spreading pigmented actinic keratosis is a rarely reported premalignant, pigmented, epidermal tumor that can be difficult to distinguish clinically from other benign and malignant pigmented lesions. In an attempt to determine the cause of clinical hyperpigmentation, seven lesions from five patients were examined by light microscopy. Three of these lesions were also examined using electron microscopy. Findings from these studies indicate that hyperpigmentation is due to enhanced melanosome formation and distribution and not to a melanocytekeratinocyte melanosome transfer block.

(Arch Dermatol 1988;124:680-683)

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