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June 1988

Ketoconazole Today

Arch Dermatol. 1988;124(6):965-966. doi:10.1001/archderm.1988.01670060089030

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As Jones states in his foreword to this text, the introduction of ketoconazole therapy was an "epochal event in medical mycology." It began the age of orally administered azole treatment for fungal infections. In this book, much of what has been learned over the past eight years about ketoconazole and its clinical actions is reviewed in scholarly fashion and in a clear style, with good use of figures for data presentation. Also, the knowledge of pathophysiology that has been acquired from the use of ketoconazole is emphasized. The six chapters in the text cover the antimicrobial properties of ketoconazole, clinical experience with the drug in superficial fungal infections, systemic infections and subcutaneous mycoses, safety of ketoconazole therapy in clinical practice, and new areas of research interest. The literature on ketoconazole is completely reviewed and, in general, conservatively interpreted, primarily by Clissold, a New Zealander associated with ADIS Press, who wrote

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