To the Editor.—
Transepidermal elimination (TEE) is a mechanism by which a substance is eliminated through the epidermis.1 Although more common in disorders associated with altered connective tissue, it also occurs in melanocytic nevi. In nevi, it has been noted in about 2% of cases.2The Spitz nevus (spindle and epithelioid cell nevus or benign juvenile melanoma) is a benign tumor found predominantly in children and adolescents.3 In a recent review of TEE of nevus cells in the Archives, Kantor and Wheeland4 reported three cases of benign melanocytic tumors with TEE, one a Spitz nevus. Transepidermal elimination of nevus cells of a Spitz nevus was also present in one of the six cases reported by Yuki et al.2 Weedon and Little3 reported that 36% of 211 cases of Spitz nevi showed evidence of an upward migration of nevus cells within the epidermis. In four
Merot Y. Transepidermal Elimination of Nevus Cells in Spindle and Epithelioid Cell (Spitz) Nevi. Arch Dermatol. 1988;124(9):1441–1442. doi:10.1001/archderm.1988.01670090083022
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