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November 1988

Hemorrhagic Bullous AmyloidosisA Histologic, Immunocytochemical, and Ultrastructural Study of Two Patients

Arch Dermatol. 1988;124(11):1683-1686. doi:10.1001/archderm.1988.01670110043009

• In patients with bullous hemorrhagic amyloidosis of the skin, the skin lesions were the first manifestations of a plasma cell dyscrasia. Both cases were characterized by similar clinical, histologic, and ultrastructural findings showing an intradermal blister within deposits of amyloid substances. Immunohistologic investigations with a panel of antibodies directed against amyloid fibril proteins showed reactivity of the amyloid deposits with an anti-A X serum in both patients.

(Arch Dermatol 1988;124:1683-1686)