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November 1988

Human Immunodeficiency Virus-Neutralizing Serum Samples in Healthy Control Subjects With Resolved Subacute Cutaneous Lupus Erythematosus

Author Affiliations

Biomedical Sciences Division Algorithms Inc Northridge, CA 91325; Clinical Neuroscience Branch National Institute of Mental Health Bethesda, MD 20892; Department of Psychiatry University of Southern California Los Angeles, CA 90007

Arch Dermatol. 1988;124(11):1724-1725. doi:10.1001/archderm.1988.01670110080025

To the Editor.—  Subacute cutaneous lupus erythematosus (SCLE) is a common form of chronic lupus erythematosus.1,2 It has a wide variety of clinical presentations and prognoses.3,4 Genetic predisposition, altered immunity, hormones, ultraviolet light, drug reactions, and viruses have been cited as possible causal cofactors.5 We report preliminary evidence for a viral cofactor in SCLE that cross-reacts with human immunodeficiency virus (HIV), the infectious agent in acquired immunodeficiency syndrome (AIDS). This is not to suggest that a viral cofactor for SCLE will be a retrovirus, nor that it is sexually transmitted. Rather, the inference is of a similarity between HIV antigens and other antigens to which patients with SCLE have been exposed.We conducted preliminary serologic studies on the longterm use of inactivated polio vaccine as a treatment for symptomatic HIV infection.6,7 A conserved domain of poliovirus has sequence similarities to the anti-HIV agent peptide T.8

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