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December 1988

Pachydermoperiostosis With Gastric Hypertrophy, Anemia, and Increased Serum Bone Gla-Protein Levels

Author Affiliations

From Unité de Dermatologie, Centre Hospitalier Universitaire, Bicêtre, France (Dr Venencie); Institut National de Transfusion Sanguine (Dr Boffa), and Départements d'Anatomie Pathologique (Dr Verola), de Radiologie (Dr Frija), de Médecine Interne (Dr Pillet), and Clinique Dermatologique (Dr Puissant), Hôpital Saint-Louis, Paris; Unité INSERM 234, Hôpital E. Herriot, Lyon, France (Dr Delmas); and Service de Dermatologie, Hôpital Mustapha, Algiers, Algeria (Dr Benkaïdali).

Arch Dermatol. 1988;124(12):1831-1834. doi:10.1001/archderm.1988.01670120047009

• We evaluated a patient in whom pachydermoperiostosis occurred in conjunction with anemia and gastric hypertrophy. The mechanism of the anemia appears multifactorial because, besides a myelofibrosis, a serum inhibitor of the late stage of erythropoiesis was detected. The elevated serum bone Gla-protein (osteocalcin) favors the hypothesis that primary hypertrophic osteoarthropathy represents an imbalance between increased osteoblastic bone formation and normal bone resorption.

(Arch Dermatol 1988;124:1831-1834)

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