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December 1988

The Graft-vs-Host ReactionAn Iatrogenic Model for a Number of Skin Disorders

Arch Dermatol. 1988;124(12):1849-1850. doi:10.1001/archderm.1988.01670120065012

In this issue and in the August issue of the Archives appear two additional contributions to our knowledge of the involvement of skin in the human graft-vs-host (GvH) reaction.1,2 Employed at first for the constitution of immunity in children with various congenital immunodeficiency disorders, the use of bone marrow transplantation was later extended to acquired deficiences, especially aplastic anemia. More recently, transplantation of bone marrow has become an essential component in the management of lymphomatous and leukemic malignancies. Hematopoietic reconstitution after destruction of malignant cells by radiation and chemotherapy has led to a remarkable improvement in prognosis for patients with these disorders. What were formerly almost uniformly lethal illnesses have now become diseases with a good chance for long-term remission, even apparent "cure." This is especially true of childhood leukemia.

The GvH reaction has from the beginning been amajor obstacle to the use of bone marrow transplantation.

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