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December 1988

Use of Lindane

Author Affiliations

Research Department Reed & Carnrick 1 New England Ave Piscataway, NJ 08855

Arch Dermatol. 1988;124(12):1868-1869. doi:10.1001/archderm.1988.01670120074018

To the Editor. —  In In his letter, published in the March 1988 issue of the Archives, Solomon1 questioned whether the optimal dose of lindane had been established. It is true that lindane is sold in Europe as a 0.3% solution. However, in our entomology laboratory, we tested the effectiveness of various concentrations of lindane in killing laboratorybred lice. We found that as the concentration dropped below 1.0% so too did the pediculicidal activity, precipitously so when the concentration reached 0.33% (Figure). This may explain why most of the reports of lindane resistance have come from Europe, where, probably, a sublethal concentration is used.Solomon also suggests that potential toxicity to lindane could be reduced by assuring that the lotion is washed off at a specified time. Examination of the report by Ginsburg et al2 demonstrates that this would probably not achieve the intended goal. In their study, a lindane lotion was applied to the entire body of scabetic infants and children

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