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January 1989

Penicillamine Dermatopathy With LymphangiectasesA Clinical, Immunohistologic, and Ultrastructural Study

Arch Dermatol. 1989;125(1):92-97. doi:10.1001/archderm.1989.01670130094014

• The term penicillamine dermatopathy refers to the characteristic hemorrhagic skin lesions found in persons receiving long-term penicillamine therapy for either Wilson's disease or cystinuria. These lesions are thought to develop as a result of faulty collagen and elastin synthesis. We describe a patient with Wilson's disease who developed extensive penicillamine dermatopathy. In addition, histologic, immunochemical, and ultrastructural studies revealed multiple lymphangiectases with blood vessel to lymphatic anastomosis within these lesions, a finding not previously reported. The possible relationship to defective collagen and elastin formation are considered.

(Arch Dermatol 1989;125:92-97)