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February 1989

Borrelia burgdorferi and Localized Scleroderma

Author Affiliations

Dermatology Department Hôpital Henri Mondor 94010 Créteil, France; Bacteriology Department Hôpital Claude Bernard 10, Avenue de la Porte d'Aubervilliers 75019 Paris, France

Arch Dermatol. 1989;125(2):297. doi:10.1001/archderm.1989.01670140149031

To the Editor.—  Aberer et al,1 in Austria, have suggested that morphea might be related to Borrelia burgdorferi infection. These authors found antibodies to B burgdorferi in five of ten patients with morphea in one study and eight of 15 patients in another study, which used the enzyme-linked immunosorbent assay.2

Patients and Methods.—  We tested for antibodies to B burgdorferi in 17 patients (15 women and two men; mean age, 38.8 years) with a history of four months to 13 years of localized scleroderma. Serologic evaluation was performed by immunofluorescence with B burgdorferi strain B31, the antigen being prepared as described by Russell et al.3 All patients had negative antibody titers (< 1:256).

Results.—  Our results are in agreement with those of Muhlemann et al4 in the United Kingdom, Hansen et al5 in Denmark, and Hoesly et al6 in the United States. In West

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