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May 1989

Human Papillomavirus-35-Positive Bowenoid Papulosis of the Anogenital Area and Concurrent Human Papillomavirus-35-Positive Verruca With Bowenoid Dysplasia of the Periungual Area

Author Affiliations

From the Department of Dermatology, Zurich University Hospital (Drs Rüdlinger and Schnyder); and the Institute of Immunology and Virology, Zurich University (Drs Rüdlinger, Grob, and Yu).

Arch Dermatol. 1989;125(5):655-659. doi:10.1001/archderm.1989.01670170069012

• We describe a 42-year-old woman with human papillomavirus (HPV)-35-positive bowenoid papulosis in her anogenital region and HPV-35-positive verruca with bowenoid dysplasia on her right ring finger. The anogenital lesions were diagnosed 11 years before the lesion on her finger developed. We were not able to cure her bowenoid papulosis, since new lesion formation occurred continuously. As pruritus of the anogenital area was always present, scratching may have resulted in autoinoculation. The fact that a "mucosal-type" HPV, which was cloned from a cancer of the uterine cervix, was detected in a dysplastic periungual lesion seems noteworthy. Viral copy numbers appeared to be much higher in the periungual lesion, indicating that in our patient HPV-35 was able to replicate well outside the anogenital area. There are as yet insufficient data on the epidemiology of HPV-35 to conclude how common extragenital infection with HPV-35 is.

(Arch Dermatol 1989;125:655-659)

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