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June 1989

The Discrimination Between CD8+ Cytotoxic and CD8+ Suppressor Lymphocyte Subsets Within Cutaneous Infiltrates

Author Affiliations

Clinica Dermatologica Università via Gramsci 14 I-43100 Parma, Italy

Arch Dermatol. 1989;125(6):844-845. doi:10.1001/archderm.1989.01670180116021

To the Editor.—  I was very interested to read the article by Paller et al, entitled "T-lymphocyte Subsets in the Lesional Skin of Allogeneic and Autologous Bone Marrow Transplant Patients," that was published in the December 1988 issue of the Archives.1 In fact, the possibility of discriminating between one another the two main subclasses of CD8+ lymphocytes, namely, the CD8+ cytotoxic subset vs the CD8+ suppressor subset, seems very important in order to understand the functional role(s) played by CD8+ cells in infiltrating the inflammatory or neoplastic lesional skin.Paller and coworkers state that, since they found neither CD16+ cells nor CD11+ cells in the skin of patients with acute graft-vs-host disease, the infiltrating CD8+ cells are probably cytotoxic.1 I would like to suggest the opportunity to also employ, in order to add strength to such an assumption, the 9.3 monoclonal antibody, since the expression of the surface polypeptides recognized

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