[Skip to Navigation]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
July 1989

Special Techniques in Dermatology

Author Affiliations

From the Division of Dermatopathology, Department of Dermatology, University of Pennsylvania, Philadelphia.

Arch Dermatol. 1989;125(7):963-974. doi:10.1001/archderm.1989.01670190097014

• Beyond routine hematoxylin-eosin histologic examinations, specialized diagnostic techniques allow examination of biopsy material for subtle morphological and functional alterations. Morphological analytic techniques (1-μm section analysis, transmission electron microscopy, x-ray probe microanalysis, and digital image analysis) and functional analytic techniques (immunofluorescence, immunohistochemistry, and molecular biologic techniques) are valuable diagnostic tools. These techniques have applications in evaluating cutaneous T-cell lymphoma and atypical lymphocytic infiltrates, vesiculobullous disorders, lupus erythematosus and collagen vascular diseases, vasculitis, poorly differentiated tumors, storage diseases, and infections.

(Arch Dermatol. 1989;125:963-974)