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July 1989

Is Podophyllin Safe for Use in Pregnancy?-Reply

Author Affiliations

Sunnybrook Medical Center 2927 Lawrence Ave E Scarborough Ontario, Canada M1P 2S8

Arch Dermatol. 1989;125(7):1001. doi:10.1001/archderm.1989.01670190135023

In Reply.—  I would like to thank Dr Sundharam for his comments concerning my article on the use of podophyllin. I had hoped that my somewhat controversial stance would generate useful discussion about an area of therapeutics that I felt was largely unresolved.The original article was considerably longer and more detailed. Because of spacing restrictions, it was shortened, and I feel that, as a result, the full impact of my argument was not presented.I am not proposing that podophyllin is safe for use in pregnancy. I am simply saying that, in my opinion, it has not been proven unsafe. These two positions are quite different. I reviewed the literature and analyzed the reports and showed that, in each case, there was no proof that podophyllin was responsible. In all cases there were important histories of substance abuse, general anesthetics, or surgical intervention that may have played an important part. I