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August 1989

Systemic Sclerosis Associated With Multiple Sclerosis

Author Affiliations

Department of Dermatology University of Tokyo 7-3-1, Hongo, Bunkyo, Tokyo, Japan

Department of Dermatology University of Tokyo, Branch Hospital 3-28-6, Mejirodai, Bunkyo, Tokyo, Japan

Arch Dermatol. 1989;125(8):1145. doi:10.1001/archderm.1989.01670200121024

To the Editor.—  Multiple sclerosis is a chronic demyelinating disease that affects the central nervous system. The characteristic pathologic feature is the breakdown of the myelin sheath, with relative sparing of axons. Recently, an immunologic disorder has been found, and it has been said that an autoimmune basis may be related to the pathogenesis of the disease. In this study, we report a case of systemic sclerosis associated with multiple sclerosis.

Report of a Case.—  A 42-year-old woman was healthy until 1974, when she developed dysesthesia in the left leg. Paraplegia in both legs and gait disturbance appeared in 1975, and paropsis and dysuria were noted in 1976. Results of a physical examination revealed reduced light reflex of the left eye, decreased sensation below the C8 level, and muscle weakness in her left leg. Hyperactivity of the deep tendon reflexes and Babinski's sign were detected. Multiple sclerosis was diagnosed and

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