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September 1989

Progressive Erythematous and Atrophic Eruption in a Patient With Chronic Myelogenous Leukemia

Author Affiliations

Northwestern University Medical School and Veterans Administration Lakeside Medical Center, Chicago, Ill

Arch Dermatol. 1989;125(9):1269-1270. doi:10.1001/archderm.1989.01670210107022

REPORT OF A CASE  A 71-year-old man presented to the Veterans Administration Lakeside Medical Center, Chicago, Ill, with a 3-year history of a progressive erythematous and atrophic eruption, predominantly on the thighs and flanks, accompanied by general pruritus (Fig 1). Neither the skin lesions nor the pruritus responded to treatment with emollients, topical steroids, or antihistamines; a trial of UV light in the B range resulted in worsening of his symptoms. His medical history was remarkable for a myeloproliferative disorder, a probable variant of chronic myelogenous leukemia (Philadelphia chromosome-negative), which was diagnosed soon after the appearance of the cutaneous changes. The patient had originally received hydroxyurea for his leukemic disorder without response, and subsequently had two courses of radiation to the spleen and a course of busulfan, which was effective. Although the patient appeared to be in clinical leukemic remission, the cutaneous process continued to progress. His other medical history

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