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September 1989

Diminished Cutaneous Hair Density in Dysplastic Nevus Syndrome

Author Affiliations

Division of General Medicine, Clinical Epidemiology, and Health Service Research Department of Internal Medicine The University of Iowa College of Medicine Iowa City, IA 52242

Arch Dermatol. 1989;125(9):1287. doi:10.1001/archderm.1989.01670210125030

To the Editor.—  Review of clinical and laboratory investigations has suggested that an etiologic relationship may exist between the melanocytes of the hair follicles and some of the pigmented lesions.1,2 Normally, the coordinated growth of follicular melanocytes and keratinocytes occurs, and the developing cutaneous and scalp hairs acquire pigment. It is hypothesized that, if the keratinocytes of the hair follicle fail to grow, proliferation of the follicular melanocytes may lead to the development of a pigmented lesion. Thus, diminished cutaneous hair density and increased pigmented lesions may both be manifestations of aberrant hair follicle growth. To further consider the relationship between cutaneous hair and pigmented lesions, the present investigation of cutaneous hair density in dysplastic nevus syndrome was undertaken.Ten of the patients who are followed up by the Department of Dermatology of the University of Iowa Hospitals and Clinics, Iowa City, for dysplastic nevi agreed to participate