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October 1989

Dermatological Application of Cyclosporine

Author Affiliations

Department of Dermatology Second School of Medicine University of Naples Via S. Pansini, 5 80131 Naples, Italy

Arch Dermatol. 1989;125(10):1430-1431. doi:10.1001/archderm.1989.01670220128023

To the Editor.—  In the September 1986 issue of the Archives, Biren and Barr1 postulated that topical application of cyclosporine A could be efficacious in the treatment of cutaneous diseases characterized by a T-cell infiltrate. Frances et al2 subsequently reported that topically applied cyclosporine A had been effective in the treatment of oral erosive lichen planus.

Report of Cases.—  During the last year, we had the opportunity to study seven patients who were affected with oral erosive lichen planus that was not associated with internal diseases. All of the patients were unresponsive to traditional forms of treatment. Therefore, they were treated by means of topical applications of 10% cyclosporine A in Labrafil (absolute ethyl alcohol, 10%; oleic polyoxylate glycerides, 30%; and a sufficient quantity of olive oil to make) four times a day (100 mg/d) for 2 months, and then two times a day (50 mg/d) for 2

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