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October 1989

Topical Application of Cyclosporine on Guinea Pig Allergic Contact Dermatitis

Author Affiliations

Department of Dermatology Second School of Medicine University of Naples Via S Pansini, 5 80131 Naples, Italy

Arch Dermatol. 1989;125(10):1431-1432. doi:10.1001/archderm.1989.01670220129025

To the Editor.—  We were very interested in the article by Nakagawa et al1 in the June 1988 issue of the Archives, concerning the effect of topical application of cyclosporine A on guinea pig allergic contact dermatitis.1 The authors found the drug to be effective in suppressing skin reactions to dinitrochlorobenzene in previously sensitized animals.On the other hand, a recent study where topical cyclosporine A was used in human allergic contact dermatitis, according to the method standardized by Sukanio et al,2 led us to negative results.We studied 14 patients affected with proven allergic contact dermatitis. Pretreatment of the patch test area with cyclosporine A in different concentrations (0.1% to 1% to 10% in Labrafil) did not lower the intensity of the positive patch test reaction. According to the literature,2 only 0.25% desoxymethasone was able to inhibit the eczematous response to the hapten.3To the

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