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Nonsteroidal Anti-inflammatory Drugs is volume 2 of the Karger series Pharmacology and the Skin. This book represents a progress report on the pharmacology of nonsteroidal anti-inflammatory drugs in the context of the skin, with particular emphasis on the development of topical formulations of nonsteroidal anti-inflammatory drugs. This book consists of eight chapters written by 12 authors. The topics covered include the role of reactive oxygen species in inflammation, formulation of anti-inflammatory agents, in vitro models for the evaluation of anti-inflammatory drug action, effects of anti-inflammatory drugs on cutaneous inflammation and blood vessels, in vitro animal models for studying drug action, topical nonsteroidal antiinflammatory drugs, and adverse cutaneous reactions to nonsteroidal anti-inflammatory drugs.
A recurring theme in this book is that there is no convincing evidence that topical or systemic nonsteroidal anti-inflammatory drugs are of therapeutic benefit in the treatment of skin diseases in man. This theme immediately raises the question