• Two rare cases of distinctive thymic remnants occurring in the skin are described. The lesions were present at birth, and involved the side of the neck. One child had a complete cleft lip and palate. The other had multiple congenital anomalies consistent with a rare syndrome entitled branchio-oculo-facialsyndrome. Microscopically, lobular foci were present in the dermis and consistent with both prethymic and thymic remnants. Immunohistochemical studies using antibodies to T cells and B cells showed a distribution similar to that seen in normal thymus. Dermal thymus appears to be a distinct entity and may be associated with other faciobranchial defects.
(Arch Dermatol. 1989;125:1681-1684)
Barr RJ, Cruz DJS, Pearl RM. Dermal Thymus: A Light Microscopic and Immunohistochemical Study. Arch Dermatol. 1989;125(12):1681–1684. doi:10.1001/archderm.1989.01670240081019
Customize your JAMA Network experience by selecting one or more topics from the list below.
Create a personal account or sign in to: