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December 1989

Dermal Thymus: A Light Microscopic and Immunohistochemical Study

Author Affiliations

From the Dermatopathology Laboratory, Department of Dermatology, University of California Irvine Medical Center (Dr Barr); the Department of Pathology, St John's Mercy Medical Center, St Louis, Mo (Dr Santa Cruz); and The Permanente Medical Group Inc, Santa Clara, Calif (Dr Pearl).

Arch Dermatol. 1989;125(12):1681-1684. doi:10.1001/archderm.1989.01670240081019

• Two rare cases of distinctive thymic remnants occurring in the skin are described. The lesions were present at birth, and involved the side of the neck. One child had a complete cleft lip and palate. The other had multiple congenital anomalies consistent with a rare syndrome entitled branchio-oculo-facialsyndrome. Microscopically, lobular foci were present in the dermis and consistent with both prethymic and thymic remnants. Immunohistochemical studies using antibodies to T cells and B cells showed a distribution similar to that seen in normal thymus. Dermal thymus appears to be a distinct entity and may be associated with other faciobranchial defects.

(Arch Dermatol. 1989;125:1681-1684)