To the Editor.—
I enjoyed the article published by Alcalay and coworkers1 that appeared in the Archives. In this article, these authors studied the variations in the number and morphology of Langerhans' cells in the epidermal component of squamous cell carcinoma, as well as in unaffected skin in the vicinity of the tumor and unexposed areas of the same person. The authors noted that there is a decreased number and altered morphology of Langerhans' cells in some squamous cell carcinomas of the skin.In 1988, we2 studied the number of S100 protein-positive cells in inflamed and noninflamed keratoacanthoma and squamous cell carcinoma. We observed that the number of Langerhans' cells per high-power field was markedly increased in inflamed keratoacanthoma when compared with early, noninflamed and inflamed squamous cell carcinoma. We hypothesized that increased numbers of Langerhans' cells in inflamed keratoacanthoma were part of the process that results in
Penneys NS. Langerhans' Cells Density and Morphology. Arch Dermatol. 1990;126(1):119. doi:10.1001/archderm.1990.01670250125021
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