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February 1990

Langerhans Cells in Squamous Cell Carcinoma

Author Affiliations

Department of Dermatology University of Newcastle-Upon-Tyne The Royal Victoria Infirmary Newcastle-Upon-Tyne NE1 4LP, England

Arch Dermatol. 1990;126(2):247-248. doi:10.1001/archderm.1990.01670260119027

To the Editor.—  Alcalay et al1 report a reduction in numbers of Langerhans cells (LC) and alterations in their morphology, with loss of dendrites in some squamous cell carcinomas. They speculate that tumor proliferation may destroy the dendrites or that the LC surrounded by the malignant keratinocytes may lack a stimulus that is required to maintain dendritic morphology. Other workers have noted that following application of potent sensitizers such as dinitrofluorobenzene to mice,2 or urushiol3 or dinitrofluorobenzene4 to guinea pigs, LC numbers were reduced and adenosine triphosphatase staining patterns were altered with loss of dendritic processes. We have observed apparently similar changes in LC density and morphology following appplication of the sensitizer dinitrochlorobenzene to human skin. We have previously shown that the degree of allergic sensitivity induced by a range of doses of dinitrochlorobenzene follows predictable log dose-response relationships.5 We were therefore interested to see

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