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February 1990

Multicentric Reticulohistiocytosis: Response to Dexamethasone Pulse Therapy

Author Affiliations

Department of Dermatology and Sexually Transmitted Diseases University College of Medical Sciences, Shahdara Delhi 110095, India

Department of Dermatology and Sexually Transmitted Diseases All India Institute of Medical Sciences New Delhi, India

Arch Dermatol. 1990;126(2):251-252. doi:10.1001/archderm.1990.01670260123032

To the Editor.—  Reticulohistiocytosis is generally regarded as a granulomatous histiocytic reaction to a hitherto unrecognized stimulus.1 It has a spectrum ranging from solitary cutaneous reticulohistiocytoma2 through diffuse cutaneous reticulohistiocytosis, without systemic involvement,3 to multicentric reticulohistiocytosis with systemic manifestations.4 The lesions in all these conditions have identical light microscopic and ultrastructural findings, suggesting that they are variants of the same disease with similar etiologic and pathogenetic mechanisms.

Report of a Case.—  A 23-year-old married woman presented with a 5-month history of asymptomatic, widespread, multiple, reddishbrown papular lesions, with slow progressive spread and focal spontaneous evolution. At the onset of the cutaneous eruption, the patient had fever, mild arthralgia of the knees, and redness of the eyes; all of these symptoms subsided spontaneously. Her general health was otherwise good, and there were no systemic symptoms at the time of admission.Examination revealed discrete and grouped reddish-brown,

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