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August 1990

Cutaneous Formation of Vitamin D in Psoriasis

Arch Dermatol. 1990;126(8):1107-1108. doi:10.1001/archderm.1990.01670320131033

To the Editor.—  Vitamin D action requires epidermal synthesis (interaction of ultraviolet light B [UV-B] photons and 7-dehydrocholesterol molecules) and systemic activation in the liver and kidneys (to 25-dihydroxyvitamin D [25-OH-D] and 1,25-dihydroxyvitamin D [1,25-(OH)2-D]). A subtle or minimal impairment of this process was evaluated in the present study of patients with psoriasis of varying extent. The rationale for the investigation was (1) psoriasis is an epidermal disorder, and (2) psoriasis has been treated with the active vitamin D metabolite 1,25-(OH)2-D.1,2

Materials and Methods.—  The study population was composed of 11 patients with psoriasis and 11 control subjects. Patients with psoriasis consisted of six men and five women with a mean age of 34 years (range, 25 to 69 years). Ten subjects were white and one was East Asian (Oriental). All had histologically confirmed psoriasis. At the time of the study, 10 of the patients