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October 1990

Ionizing Radiation-Induced Pemphigus: Case Presentations and Literature Review

Author Affiliations


From the Dermatology Service, Brooke Army Medical Center, Fort Sam Houston, Tex.

Arch Dermatol. 1990;126(10):1319-1323. doi:10.1001/archderm.1990.01670340071011

• Reports of pemphigus following ionizing radiation exposure are rare. We report two cases and review the literature regarding this association. Characteristics common to these cases include a prodromal persistent non-specific dermatitic eruption that is often interpreted as radiation dermatitis, and latency of variable duration before the onset of a vesiculobullous eruption that begins at the portal of irradiation. Direct immunofluorescence is positive for intercellular IgG, while indirect immunofluorescence is commonly positive only at low titers; HLA correlations have not been studied. Documentation of clinical course and laboratory confirmation of the diagnosis, including hematoxylin-eosin, direct and indirect immunofluorescence, and HLA determinations (if available), should be recorded to enable further clarification of this entity.

(Arch Dermatol. 1990;126:1319-1323)

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