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November 1990

Psoriasis After Allogeneic Bone Marrow Transplantation

Author Affiliations

Service Maladies du Sang

Laboratoire d'Anatomie Pathologique

Service de Dermatologie Centre Hospitalier Regional Universitaire 49033 Angers Cedex, France

Arch Dermatol. 1990;126(11):1523. doi:10.1001/archderm.1990.01670350139033

To the Editor.—  We describe the case of a 24-year-old woman, with a typical psoriasis that appeared 6 months after allogeneic bone marrow transplantation (BMT) from a psoriatic sibling HLA donor.

Report of a Case.—  In March 1986, a 24-year-old woman without psoriasis was admitted with mediastinal lymphoblastic non-Hodgkin's lymphoma. Between May and July 1986, three courses of an adriamycin-containing regimen induced complete remission. In September 1986, BMT was performed from an HLA-identical -A1, -A2, -B12, -B13, -DR7, -DRW6, negative, mixed lymphocyte culture brother with psoriasis, but no other disease. The young woman received cyclophosphamide plus fractionated total body irradiation as a conditioning regimen and graft-vs-host disease (GVHD) prophylaxis consisted of short doses of methotrexate (at days 1, 3, 6, and 11) and cyclosporine (4 mg/kg per day) intravenously, then orally twice daily. At day 62, a transient grade II acute GVHD of the skin appeared with a relapse on

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