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December 1990

Discoid Lupus Erythematosus-Like Skin Changes in Patients With Autosomal Recessive Chronic Granulomatous Disease

Author Affiliations

Department of Dermatology

Department of Pediatrics

Department of Pathology Academic Medical Center Meibergdreef 9 1105 AZ Amsterdam, the Netherlands

Arch Dermatol. 1990;126(12):1656-1658. doi:10.1001/archderm.1990.01670360124034

To the Editor.—  Lupus erythematosus (LE)-like skin lesions have been reported regularly in carriers of X-linked chronic granulomatous disease (CGD).1 However, discoid LE lesions have been described in only three cases of autosomal recessive CGD.2,3 We describe the immunophenotyping of these lesions in two more patients.

Report of Cases.—Case 1.—  An 18-year-old boy with autosomal recessive, cytochrome-b-558positive CGD, with absence of cytosolic 47 kd phosphoprotein, presented with skin lesions on his face, back, and chest that consisted of well-defined erythematous scaling plaques with slight atrophy, telangiectasias, hypopigmentation, and hyperpigmentation (Figure).

Case 2.—  A 26-year-old man with autosomal recessive cytochrome-b-558positive CGD without the cytosolic 47 kd protein, had a dermatologic history of recurrent facial lesions during the last 6 years. Reasonably well-defined erythematous patches of various sizes with only slight scaling appeared on the face, and two welldefined lesions, reddish and scaling with

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