To the Editor.—
We observed an adult patient with sequential development of mucosal lesions typical of cicatricial pemphigoid (CP) and skin lesions clinically suggestive of early, urticarioid bullous pemphigoid (BP). Direct immunofluorescence showed a linear IgA deposition at the dermoepidermal junction in both lesions. The patient did not respond either to the classic combined treatment with diamino-dimethyl-sulfone (DDS) and steroids or to immunosuppressive agents. Interestingly, on the contrary, the mucosal and cutaneous lesions showed a specifically different response to different treatments, ie, the lesions were satisfactorily cured by low doses of tetracyclines and oral steroids, respectively. A 61-year-old man was first seen in 1986 with erythematous and erosive lesions of the conjunctival, oral (Fig 1), prepucial, and epiglottal mucosa for 8 months. Major symptoms consisted of burning and clear reduction of smell and taste sensitivity. Histologic examination, performed on a prepucial biopsy specimen, showed a subepithelial bulla and a perivascular
Fuligni A, Di Blasi A, Borgogni L, Pimpinelli N, Moretti S, Fabbri P. A Peculiar Case of Linear IgA Bullous Dermatosis. Arch Dermatol. 1991;127(1):126–127. doi:10.1001/archderm.1991.01680010138031
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