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February 1991

Acquired Ichthyosis: A New Cutaneous Marker of Autoimmunity

Author Affiliations

Department of Dermatology Hopital St Jacques 25030 Besançon Cedex, France

Arch Dermatol. 1991;127(2):263-264. doi:10.1001/archderm.1991.01680020135022

To the Editor.—  A variety of dysimmune conditions may be seen in patients with acquired ichthyosis. Among the more common are Hodgkin's disease and sarcoidosis. Font et al1 recently reported a new case of acquired ichthyosis in a patient with systemic lupus erythematosus. Evidence that acquired ichthyosis may be a new reported manifestation of collagenosis was supported by their case report, as well as by the observation we published 1 year ago.2 Our patient was suffering from mixed connective tissue disease that may be considered as a clinical and biological form of systemic lupus erythematosus.3 Acquired ichthyosis was also reported to be associated with dermatomyositis.4 In a recent review of the literature, we were not able to find other cases of collagenosis related to acquired ichthyosis.5 The association of autoimmune conditions with acquired ichthyosis indicates that abnormal host immune response may have a role in

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