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March 1991

Psoriasis, Cyclosporine, and Pregnancy

Author Affiliations

Department of Dermatology Royal Free Hospital School of Medicine Pond Street Hampstead, London NW3 2QG, England; Consultant Dermatologist The London Hospital Whitechapel, London El 1BB, England

Arch Dermatol. 1991;127(3):426. doi:10.1001/archderm.1991.01680030152030

To the Editor.—  Cyclosporine was first used in the prevention of organ graft rejection, but its potent immunosuppressive effects and apparent lack of bone marrow toxicity may make it suitable for a range of other diseases.1 Perhaps the best defined of these is psoriasis, and the drug is increasingly being used in treating this condition.2 Among the contraindications to treatment with cyclosporine is pregnancy. We report what, to our knowledge, is the first successful pregnancy in a patient taking cyclosporine for psoriasis.

Report of a Case.—  A 39-year-old woman first developed widespread guttate psoriasis at age 12 years. Despite many spells of inpatient treatment, she never obtained complete relief from symptoms, and treatment with methotrexate was started in 1973, after a normal liver biopsy. The course of her psoriasis remained troublesome and, at various times between 1973 and 1984, she was treated with hydroxyurea, razoxane, and photochemotherapy, without

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