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April 1991

Human Leukocyte Antigen Haplotype Sharing in Siblings With Psoriasis-Reply

Author Affiliations

Rheumatic Disease Unit 562 Heritage Medical Research Centre University of Alberta Edmonton, Alberta, Canada T6G 2S2

Arch Dermatol. 1991;127(4):585-586. doi:10.1001/archderm.1991.04510010153026

In Reply.  —We would like to apologize for not including the article by Karvonen and coworkers in our references.1,2 Several methodological differences distinguish his study from ours. We excluded from our study those families with a history of psoriasis on both the paternal and maternal sides to avoid multiplicity of genetic influences. A diagnosis of psoriasis was only considered in the presence of active lesions or if a history had been documented by a dermatologist. The ascertainment of all cases was blind, done without knowledge of the human leukocyte antigen (HLA) status. In the study by Karvonen and coworkers, the families were not selected at random, and special attention was given to pedigrees with HLA-B13 and -Bw37. It is unclear from their methods whether the ascertainment of psoriasis followed the same criteria as ours.Ten of the 14 families in their study had two or more siblings with psoriasis. Vertical transmission from

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