To the Editor.—
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) represent severe forms of cutaneous drug reactions. There have been 23 cases of these reactions reported in human immunodeficiency virus (HIV)-infected persons, six in the United States and 17 in Europe.1-6 We report an additional eight cases, seven with acquired immunodeficiency syndrome (AIDS) and one with acquired immunodeficiency syndrome-related complex, seen at the University of California San Francisco-affiliated hospitals in 3.5 years (Table).The patients were gay males, one of whom was also an intravenous drug user (case 8). Helper T-cell counts (available in five patients) were below 100 × 109 cells per liter. All cases were related to drug exposure, and occurred from 1 to 21 days (median, 8.0 days) after the implicated drug was initiated. Two of the patients developed reactions while hospitalized (cases 2 and 8). The eight patients had all received multiple medications,
Porteous DM, Berger TG. Severe Cutaneous Drug Reactions (Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis) in Human Immunodeficiency Virus Infection. Arch Dermatol. 1991;127(5):740–741. doi:10.1001/archderm.1991.01680040152024
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