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July 1991

Successful Use of Topical Vitamin E Solution in the Treatment of Nail Changes in Yellow Nail Syndrome

Author Affiliations

From the Departments of Dermatology (Drs Williams and du Vivier) and Analytical Pharmacy (Ms Buffham), King's College Hospital, Denmark Hill, London, England. Dr Williams is now with St John's Hospital Dermatology Centre, London, England.

Arch Dermatol. 1991;127(7):1023-1028. doi:10.1001/archderm.1991.01680060097012

• A double-blind controlled study was performed on a patient with long-standing yellow nail syndrome to investigate the potential beneficial role of topical vitamin E solution for the nail changes seen in this disorder. Three nails received active solution containing DL-α-tocopherol in dimethyl sulfoxide; three nails received dimethyl sulfoxide only; and the remainder were untreated. After 6 months of therapy, the three nails treated with active solution showed marked clinical improvement and a corresponding increase in nail growth rates. Dimethyl sulfoxide alone produced a small increase in nail growth rate and slight clinical improvement. Active solution was then applied to all of the nails for a further 6 months, resulting in clinical improvement and increased nail growth rates in the remaining nails. These beneficial effects require further study.

(Arch Dermatol. 1991;127:1023-1028)