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July 1991

Treatment of Cutaneous Sarcoidosis With Chloroquine: Review of the Literature

Author Affiliations

From the Division of Dermatology, Vanderbilt School of Medicine, Nashville, Tenn. Dr Horowitz is in private practice in Nashville.

Arch Dermatol. 1991;127(7):1034-1040. doi:10.1001/archderm.1991.01680060108015

• Systemic corticosteroids may be either contraindicated or not efficacious in treating the cutaneous manifestations occurring in 20% to 35% of patients with systemic sarcoidosis. Chloroquine phosphate has been reported to be a valuable alternative therapy for cutaneous lesions of sarcoidosis. With a judiciously determined daily dosage and regular 6-month ophthalmologic follow-up examinations, the risk of developing retinopathy can be avoided, because the daily dosage rate rather than total dose accumulation determines the development of chloroquine-induced retinopathy. We reviewed the efficacy and safety of chloroquine and its role in the treatment of cutaneous sarcoidosis.

(Arch Dermatol. 1991;127:1034-1040)

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