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July 1991

Bullous Eruption in an Infant

Author Affiliations

Royal Hallamshire Hospital and Children's Hospital, Sheffield, England

Arch Dermatol. 1991;127(7):1051-1052. doi:10.1001/archderm.1991.01680060125019

REPORT OF A CASE  A 5-month-old girl was admitted to the hospital with a 36-hour history of large tense blisters on the trunk. For 2 weeks before this event, the child's mother had noticed intermittent blotchiness of the skin. The child's birth and developmental history were normal, her mother was in good health, and the child did not receive any drugs before the onset of the eruption. Her maternal uncle had a history of a widespread rash present since infancy but had never suffered from blistering.Physical examination revealed an extensive eruption of tense bullae, mainly on the trunk (Fig 1). Some of the lesions were hemorrhagic. The remainder of the physical examination was unremarkable. A skin biopsy specimen was obtained at the site of a bullous lesion on the abdominal wall (Figs 2 through 4). Histologic examination revealed a dense cellular infiltrate in the upper third of the dermis

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