To the Editor.—
In recent years, reactipve oxygen species and lipid peroxides that are produced from reactive oxygen species in the presence of polyunsaturated fatty acids have been implicated in the pathogenesis of many inflammatory disorders, including dermatologic diseases. On the other hand, superoxide dismutase (SOD), catalase, and glutathione peroxidase, all of which effectively remove reactive oxygen species or inhibit lipid peroxidation, serve to protect the host from oxidative tissue injury. We have demonstrated elevated lipid peroxide levels in ulcerated burns, wounds, and other erosive skin lesions, and have found that individual variation in the capacity for SOD induction to scavenge reactive oxygen species or inhibit lipid peroxidation correlates well with the capacity for healing in inflammatory skin diseases.1,2 More recently, we have also suggested that the SOD induction capacity assessed by human leukocytes and the toxic herbicide, paraquat, can predict longevity and carcinogenesis in humans.3In order
Iizawa O, Kato T, Tagami H, Niwa Y. Lipid Peroxides and Superoxide Dismutase Activity in Trichophyte Lesions. Arch Dermatol. 1991;127(8):1241–1243. doi:10.1001/archderm.1991.01680070143028
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