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September 1991

Low-Dose Cyclosporine A in the Treatment of Disabling Morphea

Author Affiliations

Department of Dermatology University of Munich Frauenlobstrasse 9-11 W-8000 Munich 2, Germany

Arch Dermatol. 1991;127(9):1420-1421. doi:10.1001/archderm.1991.01680080160029

To the Editor.—  Cyclosporine A is an immunosuppressive agent that has been used primarily in transplantation medicine. It has also been used in a variety of dermatologic diseases, including severe psoriasis vulgaris,1 pyoderma gangrenosum,2 granuloma anulare,3 vitiligo,4 Behçet's disease,5 pemphigus vulgaris,6 and alopecia areata.7 In lupus erythematosus, its use has met with limited success (unpublished observations).Disabling morphea is a rare disease that is often resistant to most forms of treatment; intravenous administration of penicillin, steroids, and nonsteroidal anti-inflammatory drugs (NSAIDs) are recommended.6We describe two male patients, 50 and 40 years of age, respectively, who presented with severe, rapidly progressive disabling morphea, and who showed marked improvement on treatment with cyclosporine A, after treatment with NSAIDs, high-dose intravenous penicillin (both cases), diuretics, and high daily doses of methyl prednisolone (case 1 only) had been ineffective.

Report of Cases.—Case 1.— 

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