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October 1991

Multiple Crusted Plaques in a Woman With Systemic Lupus Erythematosus

Author Affiliations

Boston (Mass) University School of Medicine and the Center for Blood Research, Harvard Medical School, Boston

Arch Dermatol. 1991;127(10):1575-1576. doi:10.1001/archderm.1991.01680090139021

REPORT OF A CASE  A 34-year-old woman was seen in May 1988 for a progressive skin eruption on her face and trunk. Her pertinent medical history began in 1980 when she was diagnosed with systemic lupus erythematosus (SLE) after presenting with fatigue, arthralgias, leukopenia, and a positive antinuclear antibody titer of 1:250 in a homogeneous pattern. At that time, treatment with hydroxychloroquine sulfate (Plaquenil) resulted in normalization of all laboratory values and resolution of symptoms. After 2 years, hydroxychloroquine sulfate therapy was discontinued, and she was maintained symptom-free on tolmetin sodium (Tolectin) for the next several years.In October 1987, she presented with a 6-month history of asymptomatic purple discoloration and swelling of her left upper and lower eyelids. Treatment with betamethasone valerate (Valisone) cream three times daily resulted in no improvement. Laboratory studies at that time were all within normal limits, including a negative antinuclear antibody and a normal

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