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October 1991

Porphyria Cutanea Tarda and Acquired Immunodeficiency Syndrome: Pathogenetic Implications

Author Affiliations

Department of Internal Medicine Hospital Virgen de las Nieves Avda Coronel Munõz 2 E-18012 Granada, Spain; Department of Dermatology Hospital Universitario Avda Dr Olóriz, 16 E-18012 Granada, Spain; Department of Digestive Medicine (C) Hospital Virgen de las Nieves Avda Coronel Munõz, 2 E-18012 Granada, Spain

Arch Dermatol. 1991;127(10):1585-1586. doi:10.1001/archderm.1991.01680090151023

To the Editor.—  We read with interest the letter by Scannell1 on porphyria cutanea tarda (PCT) preceding the development of the acquired immunodeficiency syndrome (AIDS). The author adds two new cases to the five previously reported and states that the appearance of new cases with these associations raises the possibility that these two disorders share a pathogenetic relationship. We report a new case and comment on some pathogenetic theories.

Report of a Case.—  A 28-year-old man with a history of intravenous drug abuse and heavy use of alcohol for more than 10 years presented in 1985 for evaluation of recurrent blistering skin lesions. Physical examination revealed blisters and numerous crusted lesions on the dorsa of the hands with residual depigmented scars. Also revealed were ulcerated lesions with scarring on the outer ears, cheeks, forehead, and neck, and moderated facial hypertrichosis.Hepatoesplenomegaly was also present. Laboratory studies showed the

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