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November 1991

Are Topical Corticosteroids Useful Adjunctive Therapy for the Treatment of Psoriasis With Ultraviolet Radiation?A Review of the Literature

Author Affiliations

From the Department of Dermatology, New York (NY) University School of Medicine, and the Photomedicine Section, Charles C. Harris Skin and Cancer Pavilion, New York (NY) University Medical Center (Drs Meola, Soter, and Lim); and the Dermatology Service, New York (NY) Veterans Affairs Medical Center (Dr Lim).

Arch Dermatol. 1991;127(11):1708-1713. doi:10.1001/archderm.1991.01680100108015

• Adjunctive topical corticosteroids are often administered with UV-B phototherapy or oral psoralen plus UV-A (PUVA) photochemotherapy for the treatment of psoriasis. Five studies comparing PUVA alone with PUVA and topical corticosteroid preparations showed more rapid rates of clearing and a smaller total UV-A exposure with the latter regimen. However, one study demonstrated a higher relapse rate in association with corticosteroid use. Further studies to better define these risks are recommended. Six of seven reports evaluating the use of topical corticosteroid preparations with UV-B phototherapy failed to demonstrate an advantage to this regimen when compared with UV-B phototherapy alone. Therefore, the use of a topical corticosteroid preparation with UV-B phototherapy for the treatment of psoriasis is not recommended.

(Arch Dermatol. 1991;127:1708-1713)

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