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November 1991

Lichen Planus Associated With Anti-Liver-Kidney Microsome-Positive Chronic Active Hepatitis and Hyperthyroidism

Author Affiliations

Istituto de Clinica Dermatologica; Istituto di Patologia Medica Università di Sassari Viale Mancini 5 07100 Sassari, Italy

Arch Dermatol. 1991;127(11):1730-1731. doi:10.1001/archderm.1991.01680100134026

To the Editor.—  We report herein the case of a patient with lichen planus (LP) associated with antibodies to liver-kidney microsome (anti-LKM)-positive chronic active hepatitis (CAH) and hyperthyroidism.

Report of a Case.—  A 17-year-old girl was evaluated in our unit in October 1989 because of cutaneous and mucous lesions of 1 month's duration. She had complained of pruritus and poliphagia 10 months previously; blood chemistry studies at that time were normal. At our evaluation, skin examination revealed violaceous planar papules on the anterior surface of her lower limbs, palms, and soles. A nonerosive fine reticular eruption was noted on the vermilion surface of her lower lip and buccal mucosa on both sides of the mouth. Skin biopsy specimens taken on admission confirmed the clinical diagnosis of LP. The physical examination was otherwise normal apart from a slightly enlarged thyroid gland. Blood tests showed that the serum levels of transaminase and

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