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December 1991

Partial Lipodystrophy and Dermatomyositis

Author Affiliations

Department of Dermatology Hospital "Ramón y Cajal" Apartado 37 28034-Madrid, Spain

Arch Dermatol. 1991;127(12):1846-1847. doi:10.1001/archderm.1991.04520010088019

To the Editor.  — Partial lipodystrophy (PL) is characterized by a slow and symmetrical loss of subcutaneous fatty tissue, mainly involving the upper half of the body. We report a case of PL associated with dermatomyositis.

Report of a Case.  — In 1978, an 11-year-old boy began to notice proximal weakness in his limbs together with facial erythema; palpebral violaceous edema; and erythematous papules on his elbows, knees, and over the metacarpophalangeal joints. A diagnosis of polymyositis/dermatomyositis was made. He was treated with oral prednisone, which caused the symptoms to disappear promptly. In 1980, proximal weakness, dysphagia, dyspnea, and similar cutaneous lesions once again developed. Muscular wasting and slight articular retractions were evident. Laboratory values at that time showed the following values or results: aspartate aminotransferase, 122 U/L (normal, 0 to 40 U/L); alanine aminotransferase, 140 U/L (normal, 0 to 40 U/L); creatine phosphokinase, 303 U/L (normal, 0 to 200

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