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January 1992

Complement-Fixing Activity to Melanin-Producing Cells Preceding the Onset of Vitiligo in a Patient With Type 1 Polyglandular Failure

Author Affiliations

Institute of Semeiotica Medica; Department of Pediatrics; Department of Dermatology Padua University Via Ospedale 105 Padua, Italy

Arch Dermatol. 1992;128(1):123-124. doi:10.1001/archderm.1992.01680110137027

To the Editor.—  Complement-fixing activity to melanin-producing cells (CFA-MPC),1 also known as melanin-producing cell autoantibody,2-4 has been reported in serum samples from nine patients using the indirect immunofluorescent complement-fixation technique on normal human skin. Six patients2-4 had vitiligo associated with type 1 polyglandular autoimmune disease,5 including hypoparathyroidism, Addison's disease, and chronic candidiasis. The remaining three patients did not present with vitiligo but had candidiasis with or without hypoparathyroidism.1 On the basis of these latter three cases Nordlund,1 cited by Peserico et al,3 suggested that CFA-MPC should not be considered the cause of vitiligo, as this factor was always associated with candidiasis but seldom with vitiligo. Until now, no follow-up studies were conducted on cases with CFA-MPC without vitiligo.

Report of Cases.—  Since 1980, we have conducted follow-up studies on nine patients with type 1 polyglandular autoimmune disease and chronic candidiasis. They

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