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February 1992

Parathyroid Hormone-Related Protein in Patients With Malignant Melanoma

Author Affiliations

Department of Medicine; Department of Surgery University of California Irvine, CA 92717

Arch Dermatol. 1992;128(2):278-279. doi:10.1001/archderm.1992.01680120154033

To the Editor.—  Parathyroid hormone—related protein (PTHrP) is a hormone that was initially isolated from the tumors of patients with the syndrome of humoral hypercalcemia of malignancy. Since most patients with the syndrome from whom PTHrP was isolated had squamous cell cancers, attempts were made to try to isolate PTHrP from the skin of normal individuals.1 This was subsequently accomplished, and PTHrP was found to be present in the keratinoctyes of normal skin.2 Although PTHrP is produced in abundant amounts by keratinocytes in cell culture, the biologically active peptide has not been isolated from normal skin.1 Its presence in normal skin was inferred from the identification of PTHrP-specific messenger RNA in the epidermis3 and by immunohistochemical localization.4 Until recently, it was not clear whether PTHrP was produced only in keratinocytes or in other areas of the skin. Using affinity-purified polyclonal antiserum against synthetic try-36-PTHrP(1-36)amide, PTHrP

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