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April 1992

Anal Verrucous Carcinoma Associated With Human Papilloma Virus Type 11: Magnetic Resonance Imaging and Flow Cytometry Evaluation

Author Affiliations

Departments of Dermatology and Biochemistry; Department of Pathology and Internal Medicine; Medical Physicist Texas Tech University Health Sciences Center Lubbock, TX 79430; Departments of Dermatology and Microbiology; Department of Microbiology University of Texas Medical Branch Galveston, TX 77550

Arch Dermatol. 1992;128(4):564-565. doi:10.1001/archderm.1992.01680140148026

To the Editor.—  Anal verrucous carcinoma, also known as anal Buschke-Löwenstein tumor, is a rare neoplasm. Only 11 cases have been reported so far in the English-language literature.1 We report a case of anal verrucous carcinoma containing human papilloma virus (HPV) type 11 DNA in an episomal form. Magnetic resonance imaging (MRI) and DNA flow cytometry were used for the first time in the evaluation of verrucous carcinoma. Findings from DNA flow cytometry showed a normal diploid pattern, confirming the low malignant potential of this tumor, and an MRI scan performed preoperatively helped to delineate the depth of invasion and extent of this tumor.

Report of a Case.—  A 38-year-old bisexual white man presented with a rectal mass of 10 years' duration. Two months before seeking medical attention, the mass began to have an impact on his defecation, which became painful. His medical history was otherwise unremarkable. On examination,

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