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July 1992

Efficacy of Ivermectin in the Therapy of Cutaneous Larva Migrans

Author Affiliations

Département des Maladies Tropicales et Infectieuses Parasitologie et Santé Publique Hôpital Pitié-Salpêtrière 75013 Paris, France; Merck Sharp and Dohme 75008 Paris, France

Arch Dermatol. 1992;128(7):994-995. doi:10.1001/archderm.1992.01680170130027

To the Editor.—  Cutaneous larva migrans (creeping eruption) is a chronic serpiginous cutaneous eruption caused by penetration of the skin by infective larvae of animal hookworms (usually Ancylostoma braziliense). Spontaneous migration of larvae usually continues for several weeks and may very rarely persist for up to a year. Recommended therapy is tiabendazole (orally or topically).1 It has recently been reported that oral albendazole shows excellent efficacy.2-4 We report our experience with oral ivermectin, the current drug of choice for treating onchocerciasis.5

Patients and Methods.—  Since December 1, 1990, all patients with cutaneous larva migrans have been treated with a single 12-mg oral dose (200 μg/kg) of ivermectin in an open prospective study. Twelve patients have been enrolled (Table). They had returned from the Caribbean, West Africa, Thailand, Burundi, or the Gulf of Mexico. In four patients, the creeping eruption appeared during their stay abroad. In the others, the lag time between return and the onset of

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