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July 1992

Successful Treatment of an Antimony-Resistant American Mucocutaneous Leishmaniasis: A Case Report

Author Affiliations

División Inmunología Facultad de Ciencias Médicas Universidad Nacional de Rosario Santa Fe 3100 Rosario 2000, Argentina; Policlínico Carrasco Avellaneda y 9 de Julio Rosario 2000, Argentina; Unité 196 INSERM Institut Curi Section Biologie 26 rue d'Ulm 75005 Paris, France

Arch Dermatol. 1992;128(7):996-997. doi:10.1001/archderm.1992.01680170132029

To the Editor.—  Infection in man with several leishmania species results in a broad spectrum of clinical manifestations falling into three general categories: simple cutaneous disease, visceral or diffuse cutaneous leishmaniasis, and mucocutaneous leishmaniasis.The latter constitutes a serious clinical condition because of the involvement of the upper respiratory tract with important necrosis of soft tissue.1 As conventional therapy with pentavalent antimonials is of limited effectiveness, the need exists to develop new therapeutic modalities. We discuss the successful treatment of a patient with antimonyresistant mucocutaneous leishmaniasis with combined administration of recombinant interferon gamma and pentavalent antimonials.

Report of a Case.—  In October 1989, a 52-year-old man with an 11-year history of American mucocutaneous leishmaniasis was admitted to the hospital because an ulcerative process in the upper lip, cough, weight loss, and difficulties in swallowing. The patient, who visited from northern Argentina, was first seen in 1978 with a small

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