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Wolverton and Wilkin preface Systemic Drugs for Skin Diseases with this statement, "This text represents an attempt to increase the clinician's skill and comfort, while minimizing the anxiety that commonly accompanies the use of systemic agents for dermatologic problems. The focus of the book is clearly on `how to use' and `how to use safely' the spectrum of systemic drugs prescribed by dermatologists." This book, the work of 21 authors, is designed principally for the use of clinicians in dermatology and physicians in the primary care specialties. Initially, as I scanned through the table of contents and the outline of the book's 17 chapters, I was bothered by the paucity of topics that were authored by generally acknowledged experts. True, many of the authors are well-known dermatologists, but one does not generally associate them with discussions of drugs such as cyclosporine or methotrexate. Yet, in most areas, the authors have